A woman happily receiving medication advice from a pharmacist.

A Trusted Community-Based Pharmacy

Powered by trusted pharmacists, Picayune Drug Company is a community-based pharmacy and durable medical equipment (DME) provider. Established in 1903, we are proud to be one of the first businesses in Picayune. We continue to operate from our original location in the heart of town.

A Family of Trusted Community-Based Pharmacies

This family of pharmacies is independently owned and operated by Andrew L. Failla, RPh and Brenda B. Failla, RN. They are driven by personnally hired pharmacists, pharmacy technicians, clerks and delivery personnel we trust and consider family.

We are proud to own and operate one of the first businesses in our communities, with Picayune Drug Co. established in 1903, in Picayune, and Pearl River Drug & Soda Fountain established in 1954 in Poplarville.

Small Town Feel

Picayune Drug Co. and Pearl River Drug & Soda Fountain both can be found among the history and tradition of their respective towns. Both locations are set within the historic business district and are operating from their original locations in the heart of town.

These two unique pharmacy locations gives rise to a sense of history and tradition. They are among buildings constructed in a style predating modern urban planning and featuring unique designs, materials and craftsmanship that feels connected to the past.

Main Street America

Picayune Drug Co. and Pearl River Drug & Soda Fountain are a proud part of Main Street America.

Main Street America is a community based approach that focuses on revitalizing downtown cental business districts by preserving history and practicing a civic focused participation in our local community. 

Expanding Our Reach

To better serve our customers within Pearl River County, Mississippi, we expanded out from our original pharmacy, Picayune Drug Co, to include Picayune Drug Company North on the north side of Picayune and our newest location Pearl River Drug & Soda Fountain in Poplarville, MS.

A healthcare professional holding multiple blister packs of pills.

Easy Access Drive-Thru and Hospital Proximity

Our North location is designed to serve customers on the north side of town. Enjoy the convenience of a drive-thru and easy access to the hospital for quick prescription refills.

Empty hospital room with a bed and medical equipment.

Durable Medical Equipment

Complete line of medical equipment devices and supplies to assist you in activities of daily living.

A modern, minimalist wheelchair with a sleek white seat and red frame.

Community Home Care Pharmacy (Long-term care pharmacy)

Serving long-term care facilities such as nursing homes, assisted living facilities, personal care homes and hospice agencies.

Expanding Our Reach

To better serve our community, we opened Picayune Drug Company North. The North location offers a drive-thru and is conveniently located near the hospital for quick prescription fills.

A healthcare professional holding multiple blister packs of pills.

Easy Access

Our North location is designed to serve customers on the north side of town.

A woman reading a product label in a store aisle.

Drive-Thru and Hospital Proximity

Enjoy the convenience of a drive-thru and easy access to the hospital for quick prescription refills.

A variety of colorful capsules and white tablets scattered on a wooden surface.

Independently Owned

Both stores are independently owned and operated by Andrew L. Failla, RPh, and his wife, Brenda B. Failla, RN.

A Mission Rooted in Your Wellness

Our mission is to improve the health and wellness of our customers in such a professional and friendly manner that it separates us from the rest. We maintain the highest standard of principles, morals, rights, dignity, confidentiality, and legal conduct for each individual customer. We are dedicated to providing our customers with the best service achievable. We strive to provide quality products at fair market prices while applying our knowledge, experience, and skills when assisting our customers. We are continually learning and growing as health care professionals so we can provide the best care possible.

Pharmacist in white coat holding a clipboard in a pharmacy.
Confident male pharmacist in white coat with arms crossed in pharmacy.

Community-Focused Team

We take pride in being a local business, which is why we hire staff from within our community. Our employees and owners work closely together like a family, supporting each other’s success and well-being.

Supporting Local Causes

Our focus is always on supporting causes that benefit Pearl River County communities and residents.

Handshake in a pharmacy with capsules spilled beside.

We Care for You

With a focus on personalized service, our team ensures that every customer feels cared for. Feel free to connect with us for all your needs.